Understand insulin resistance, its impact on weight and metabolism, symptoms and treatment options

Insulin resistance is a condition in which the body's cells become less sensitive to insulin, so the pancreas must secrete more and more insulin to maintain normal blood sugar levels. It's like a "key and lock" — insulin is the key that opens the cell door for glucose, and in resistance the locks rust.
Insulin resistance is the main cause of type 2 diabetes, metabolic syndrome and obesity. In Lithuania, about 30% of adults have some degree of insulin resistance, and most don't know about it.
Most people feel no symptoms until the condition is advanced. Here's what to look out for:
Fatigue after meals (especially after a carbohydrate-rich one), accumulation of abdominal fat, dark skin patches (on the neck, in the armpit area), skin tags, high blood pressure.
Difficulty losing weight, cravings for sweets and carbohydrates, hunger soon after a meal, elevated blood triglycerides, low HDL ("good") cholesterol.
In women: irregular periods, PCOS, acne. In men: reduced testosterone, decreased libido.
| Cause | Mechanism | Strength of effect |
|---|---|---|
| Overweight / obesity | Visceral fat releases inflammatory cytokines that reduce insulin sensitivity | Very high |
| Sedentary lifestyle | Muscles are the main glucose "consumers". Unused muscles become insulin resistant | High |
| Sugar and refined carbohydrates | Constant insulin spikes "exhaust" the receptors | High |
| Chronic stress | Cortisol increases blood sugar, which requires more insulin | Intermediate |
| Sleep Deprivation | One sleepless night can reduce insulin sensitivity | Intermediate |
| Genetics | A predisposition can be inherited (especially if parents had type 2 diabetes) | Intermediate |
| Chronic inflammation | Inflammatory markers (CRP, IL-6) directly interfere with insulin signaling | Intermediate |
Use a diary or app. Weekly trends are more important than daily fluctuations. Regularly measure not only weight but also circumferences.
2–3 liters per day. Water aids digestion and metabolism and reduces false hunger.
Quality sleep is essential for hormonal balance, muscle recovery, and appetite control.
Even 30 minutes of walking per day can significantly improve metabolism and mood.