Everything about resveratrol: a polyphenol from red wine and grape skins, known for its antioxidant, anti-inflammatory, and anti-aging properties. Trans-resveratrol, doses, bioavailability, and practical recommendations.

Resveratrol is a natural polyphenol (stilbenoid) that plants produce as a response to stress, infections, or UV radiation. In human nutrition, the main sources are red grapes, red wine, peanuts, and dark berries. Resveratrol became popular after research into the "French paradox" — despite a high-fat diet, the French have a lower rate of heart disease, and this is partly associated with red wine.
| Form | Bioavailability | Price | Recommendation |
|---|---|---|---|
| Trans-resveratrol (standard) | Low (2%) | Cheaper | Good, higher doses |
| Trans-resveratrol + piperine | Better (5-10%) | Intermediate | Better absorption |
| Micronized resveratrol | High (15-20%) | More expensive | Best absorption |
| Resveratrol complex (with quercetin) | Improved | Intermediate | Good synergy |
The biggest problem with resveratrol is poor bioavailability — most of the resveratrol consumed is rapidly metabolized in the liver and eliminated.
Resveratrol improves endothelial function, lowers blood pressure, and inhibits blood clot formation. However, clinical data show a modest, albeit significant, effect.
Resveratrol activates sirtuins (SIRT1) — longevity genes. Human study results are contradictory — some show a positive effect, others show no effect.
Resveratrol is a strong antioxidant that neutralizes free radicals. For athletes, it may help reduce oxidative stress after intense training.
One glass of red wine (150 ml) contains about 0.5-2 mg of resveratrol. To get 250 mg (the standard supplement dose), you would need to drink ~125-500 glasses of wine. Supplements are the only practical source.
Resveratrol has a real but modest effect in humans. Laboratory studies on cells and animals show impressive results, but in humans the effect is smaller due to poor bioavailability. It is not a "placebo" — but it is also not a miraculous youth pill.
Unfortunately, no. One glass contains only 0.5-2 mg. The harm from alcohol would far outweigh any benefit of resveratrol if you tried to get a therapeutic dose through wine.